Formulation: A crystalline solid
Formal Name: (8β)-11α,15S-dihydroxy-9-oxo-prosta-5Z,13E-dien-1-oic acid
Purity: ≥99%
Formula Markup: C20H32O5
Formula Weight: 352,5
Shelf life (days): 730
CAS Number: 27415-25-4
Notes: 8-iso Prostaglandin E2 (8-iso PGE2) is one of several isoprostanes produced from arachidonic acid during lipid peroxidation.{1943} It is a potent renal vasoconstrictor in the rat.{1943,5157} 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively.{1258} When infused into the renal artery of the rat at a concentration of 4 µg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.{1943}