8-iso Prostaglandin F2α, CAS 27415-26-5

Formulation: A crystalline solid

Formal Name: 9α,11α,15S-trihydroxy-(8β)-prosta-5Z,13E-dien-1-oic acid

Purity: ≥98%

Formula Markup: C20H34O5

Formula Weight: 354,5

Shelf life (days): 730

CAS Number: 27415-26-5

Notes: 8-iso PGF2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.{320,371,855} It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine.{320,371} 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle.{6640} Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10−6 M) and I-BOP (3 x 10−7 M) with IC50 values of 1.6 x 10−6 M and 1.8 x 10−6 M, respectively.{855}

• Artikelnummer: CAY16350-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16350-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK