(±)9(10)-DiHOME, CAS 263399-34-4

Formulation: A solution in methyl acetate

Formal Name: (±)9,10-dihydroxy-12Z-octadecenoic acid

Purity: ≥98%

Formula Markup: C18H34O4

Formula Weight: 314,5

Shelf life (days): 730

CAS Number: 263399-34-4

Notes: (±)9(10)-DiHOME is the diol form of (±)9(10)-EpOME (Item No. 52400), a cytochrome P450-derived epoxide of linoleic acid (Item Nos. 90150 / 90150.1 / 21909) also known as leukotoxin.{8529} It is formed from 9(10)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils.{17057} It is toxic to Sf21 cells expressing sEH and to lacZ-expressing control cells, unlike leukotoxin, which is only toxic to cells containing sEH.{8529,17057} A mixture of 9(10)- and 12(13)-DiHOME induces cell death in rabbit renal proximal tubule cells concomitant with mitochondrial respiration dysfunction and induces lung injury, respiratory distress, and mortality in mice.{15651,5617} 9(10)-DiHOME is a toxic lipid mediator involved in acute respiratory distress syndrome (ARDS), a common and often fatal complication in severe burn victims.{17057,15651} Levels of 9(10)-DiHOME are increased in bronchoalveolar lavage fluid (BALF) from women, but not men, with chronic obstructive pulmonary disease (COPD).{42554} BALF levels are also increased in patients with allergic asthma following allergen exposure compared to patients without allergic asthma.{49189} It has been used as a plasma biomarker for sEH activity in vivo.{42555}

• Artikelnummer: CAY53400-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 53400-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK