α-Zearalenol, CAS 36455-72-8

Formulation: A crystalline solid

Formal Name: (3S,7R,11E)-3,4,5,6,7,8,9,10-octahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one

Purity: ≥98%

Formula Markup: C18H24O5

Formula Weight: 320,4

Shelf life (days): 1460

CAS Number: 36455-72-8

Notes: α-Zearalenol is a mycotoxin, an agonist of estrogen receptor α (ERα), and an active metabolite of zearalenone (Item No. 11353).{27394,31434} α-Zearalenol increases the proliferation of MCF-7 cells that endogenously express ERα (EC50 = 0.06 nM).{31434} It is also an androgen receptor antagonist (IC50 = 4,170 nM for the human receptor). α-Zearalenol induces cytotoxicity in isolated phorbol 12-myristate 13-acetate-stimulated pig neutrophils (IC50 = 59.0 µM). It increases intracellular superoxide levels when used at a concentration of 1 µM and decreases IL-8 supernatant levels in the same cells at 10 µM.{69470} It increases total and progressive motility and the levels of acrosome-reacted sperm, as well as decreases path and straight-line velocity and cell linearity, in isolated stallion sperm when used at a concentration of 100 µM.{27396} α-Zearalenol (1 mg/kg) increases uterine weight in immature female mice when administered at a dose of 1 mg/kg.{27394}

• Artikelnummer: CAY16549-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16549-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK