all-trans-4-hydroxy Retinoic Acid, CAS 66592-72-1

Formulation: A solid

Formal Name: 4-hydroxy-retinoic acid

Purity: ≥90%

Formula Markup: C20H28O3

Formula Weight: 316,4

Shelf life (days): 730

CAS Number: 66592-72-1

Notes: all-trans-4-hydroxy Retinoic acid is a metabolite of all-trans retinoic acid (Item No. 11017) formed by the cytochrome P450 (CYP) isoforms CYP26A1, B1, and C1.{34779,38575} It binds to retinoic acid receptors (RARs) with a lower affinity than other all-trans retinoic acid metabolites (IC50s = 606, 298, and 892 nM for RARα, RARβ, and RARγ, respectively, in a radioligand binding assay). It also transactivates RARs with a lower efficacy than other metabolites (EC50s = 791, 64, and 94 nM for RARα, RARβ, and RARγ, respectively) but induces transcription of a reporter plasmid equipotently. all-trans-4-hydroxy Retinoic acid inhibits cell growth, halts the cell cycle in the G1 phase, and induces differentiation of NB4 acute promyelocytic leukemia cells (EC50 = 79.8 nM).{34781}

• Artikelnummer: CAY21378
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21378-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK