Formulation: A crystalline solid
Formal Name: 1,8-dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione
Purity: ≥95%
Formula Markup: C15H10O5
Formula Weight: 270,2
Shelf life (days): 1460
CAS Number: 481-72-1
Notes: Aloe-emodin is a hydroxyanthraquinone found in Aloe vera leaves that has potent laxative action by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle.{28847} It also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species.{28848,28849} Aloe-emodin is reported to have estrogenic activity as a phytoestrogen and has been shown to inhibit breast cancer cell proliferation by downregulating ERα protein levels, and thus, suppressing transcriptional activation of the receptor.{21490,28850}