Arenobufagin, CAS 464-74-4

Formulation: A crystalline solid

Formal Name: (3β,5β,11α)-3,11,14-trihydroxy-12-oxo-bufa-20,22-dienolide

Purity: ≥95%

Formula Markup: C24H32O6

Formula Weight: 416,5

Shelf life (days): 1460

CAS Number: 464-74-4

Notes: Arenobufagin is a cardiotonic steroid that has been found in the skin secretions of the toad B. gargarizans and has anticancer activity.{52655,52656,42766,52657} It inhibits Na+/K+-ATPase activity in isolated guinea pig ventricular myocytes with an IC50 value of 290 nM.{52655} Arenobufagin (20-500 nM) induces cleavage of poly(ADP-ribose) polymerase (PARP), caspase-3, and caspase-9, as well as induces apoptosis in HepG2 hepatocellular carcinoma cells.{52656} It inhibits proliferation of HepG2, Hep3B, BEL-7402, and MCF-7 cancer cells (IC50s = 101.9, 39.8, 416.3, and 143.7 nM, respectively), as well as multidrug-resistant HepG2/adm and MCF-7/adr cancer cells (IC50s = 730 and 67.5 nM, respectively). Arenobufagin (1 mg/kg once per day, i.v.) reduces tumor growth, the number and size of lung metastases, and tumor levels of the epithelial-to-mesenchymal transition (EMT) markers vimentin and β-catenin in a PC3 mouse xenograft model.{42766} Arenobufagin (5 and 10 µM/plug) inhibits VEGF-induced angiogenesis in a Matrigel™ plug assay in mice.{52657}

• Artikelnummer: CAY30695-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30695-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK