Budesonide, CAS 51333-22-3

Formulation: A crystalline solid

Formal Name: 16α,17-[butylidenebis(oxy)]-11β,21-dihydroxy-pregna-1,4-diene-3,20-dione

Purity: ≥95%

Formula Markup: C25H34O6

Formula Weight: 430,5

Shelf life (days): 1460

CAS Number: 51333-22-3

Notes: Budesonide is a glucocorticoid and an agonist of glucocorticoid receptors (EC50 = 45.7 pM in a transactivation assay).{41565} It is selective for glucocorticoid over mineralocorticoid receptors (EC50 = 7,620 pM). Budesonide inhibits LPS-induced TNF-α release from human peripheral blood mononuclear cells (PBMCs; IC50 = 0.96 nM).{25238} It reduces levels of IL-1β and eotaxin in the lungs and the number of eosinophils and neutrophils in bronchoalveolar lavage fluid (BALF) in a rat model of ovalbumin-induced airway inflammation when administered at a dose of 3 mg/kg.{24240} Intracolonic administration of budesonide decreases colon wet weight and colonic myeloperoxidase (MPO) activity in a rat model of oxazolone-induced colitis.{52378} Formulations containing budesonide have been used in the treatment of Crohn's disease, ulcerative colitis, allergic rhinitis, and asthma.

• Artikelnummer: CAY15407-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 15407-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK