Butaprost, CAS 69685-22-9

Formulation: A solution in methyl acetate

Formal Name: 9-oxo-11α,16S-dihydroxy-17-cyclobutyl-prost-13E-en-1-oic acid, methyl ester

Purity: ≥98%

Formula Markup: C24H40O5

Formula Weight: 408,6

Shelf life (days): 730

CAS Number: 69685-22-9

Notes: Butaprost, a structural analog of PGE2, is a selective agonist for the EP2 receptor subtype. EP2 receptors are expressed on human neutrophils and on respiratory, vascular, and uterine smooth muscle.{3178,1752} Butaprost binds with about 1/10 the affinity of PGE2 to the recombinant murine EP2 receptor, and does not bind appreciably to any of the other murine EP receptors or DP, TP, FP, or IP receptors.{6640} The EC50 for the stimulation of cAMP by butaprost in COS cells transfected with the human EP2 receptor is about 5 µM, while the EC50 for PGE2 in this assay is about 43 nM.{3178} Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells.{3317}

• Artikelnummer: CAY13740-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 13740-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK