C6 Urea Ceramide, CAS 486991-52-0

Formulation: A crystalline solid

Formal Name: N-hexyl-N'-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-urea

Purity: ≥95%

Formula Markup: C25H50N2O3

Formula Weight: 426,7

Shelf life (days): 730

CAS Number: 486991-52-0

Notes: C6 urea ceramide is an inhibitor of neutral ceramidase.{46501} It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells when used at concentrations of 5 and 10 µM. C6 urea ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the 20S proteasome in HT-29 and HCT116, but not RIE-1, cells. It reduces tumor growth and increases C16, C18, C20, and C24 ceramide levels in tumor tissue in an HT-29 mouse xenograft model when administered at doses of 1.25, 2.5, and 5 mg/kg for five days.

• Artikelnummer: CAY25491-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25491-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK