Casticin, CAS 479-91-4

Formulation: A crystalline solid

Formal Name: 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one

Purity: ≥98%

Formula Markup: C19H18O8

Formula Weight: 374,3

Shelf life (days): 1460

CAS Number: 479-91-4

Notes: Casticin is a flavonol isolated from A. annua, V. trifolia, and V. agnus-castus that decreases proliferation in K562, HL-60, and Kasumi-1 leukemia cell lines (IC50s = 5.95, 4.82, and 15.56 µM, respectively).{38024} It blocks TGF-β/SMAD signaling in LX2 cells preventing activation, inhibiting proliferation, and inducing apoptosis of these hepatic stellate cells.{38025} In a mouse model of liver fibrosis, casticin (20 mg/kg) decreases TGF-β1 mRNA and phosphorylated SMAD (p-SMAD) levels. Casticin induces apoptosis in hepatocellular carcinoma (HCC) and breast cancer cells.{27628,27627} It also downregulates Twist and prevents the epithelial-mesenchymal transition (EMT) in human HCC SMMC-7721 cells.{27268}

• Artikelnummer: CAY16976-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16976-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK