CAY10410, CAS 596104-94-8

Formulation: A solution in methyl acetate

Formal Name: 11-oxo-prosta-5Z,12E,14Z-trien-1-oic acid

Purity: ≥98% (mixture of isomers)

Formula Markup: C20H30O3

Formula Weight: 318,5

Shelf life (days): 730

CAS Number: 596104-94-8

Notes: CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-Δ12,14-PGJ2 has been shown to be a potent ligand for PPARγ.{1424} Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and Δ12-PGJ2 occurs via glutathione addition across the α,β unsaturated enone.{7193} CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 µM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 µM.{12676}

• Artikelnummer: CAY18590-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 18590-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK