CAY10665, CAS 1235543-17-5

Formulation: A solution in ethanol

Formal Name: 16-[[2-(methylamino)-2-oxoacetyl]amino]-11Z-hexadecenoic acid

Purity: ≥98%

Formula Markup: C19H34N2O4

Formula Weight: 354,5

Shelf life (days): 365

CAS Number: 1235543-17-5

Notes: Isolated neonatal rat cardiomyocytes, which spontaneously beat in culture, are used to evaluate the antiarrhythmic effects of polyunsaturated fatty acids (PUFA).{21675} In this model, the ω-3 PUFA eicosapentaenoic acid (EPA, 3-10 μM) reduces the contraction rate of cells, indicating a positive antiarrhythmic effect.{21675} Cytochrome P450 metabolites of EPA are more potent, with 17,18-epoxyeicosatetraenoic acid (17,18-EET) reducing contractions at 30 nM.{18672} CAY10665 is a bioisostere of 17,18-EET which is approximately 50% more effective at reducing arrhythmic contraction frequency, without affecting amplitude, when tested at 30 nM.{19905} This disubstituted oxamide represents a stable analog of 17,18-EET which may be used to study the mechanism of regulation of cardiomyocyte contractility by EPA metabolites.

• Artikelnummer: CAY11044-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11044-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK