Chenodeoxycholic Acid, CAS 474-25-9

Formulation: A crystalline solid

Formal Name: (3α,5β,7α)-3,7-dihydroxy-cholan-24-oic acid

Purity: ≥95%

Formula Markup: C24H40O4

Formula Weight: 392,6

Shelf life (days): 1460

CAS Number: 474-25-9

Notes: Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid.{59331} It is formed from cholesterol in the liver via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. CDCA is a farnesoid X receptor (FXR) agonist that binds to FXRs in a TR-FRET assay (EC50 = 13 µM) and induces FXR transactivation in a reporter assay.{13291,9823} It induces transcription of the gene encoding the Nrf2 target glutamate cysteine ligase (GCL) in primary hepatocytes and HepG2 cells when used at concentrations ranging from 25 to 100 µM.{16793}

• Artikelnummer: CAY10011286-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10011286-25
• Green Labware: Nein
• Verpackungseinheit: 25 g
• Mengeneinheit: STK