Cholestanol, CAS 80-97-7

Formulation: A solid

Formal Name: (5α)-cholestan-3β-ol

Purity: ≥95%

Formula Markup: C27H48O

Formula Weight: 388,7

Shelf life (days): 1460

CAS Number: 80-97-7

Notes: Cholestanol is a cholesterol metabolite formed by oxidation and an intermediate in the biosynthesis of chenodeoxycholic acid (Item No. 10011286).{47049} Cholestanol (10 µg/ml) induces apoptosis in cornea and lens epithelial cells and increases the activity of IL-1β converting enzyme (ICE) and CPP32 proteases.{47050} Dietary administration of 1% cholestanol to mice increases serum and liver cholestanol levels and leads to corneal opacities and gallstones and in rats it leads to cholestanol deposition in the cerebellum.{47051} Cholestanol levels are increased in plasma of patients with cerebrotendinous xanthomatosis (CTX), a disease characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.{47052}

• Artikelnummer: CAY9003101-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9003101-25
• Green Labware: Nein
• Verpackungseinheit: 25 g
• Mengeneinheit: STK