Cholic Acid-d4, CAS 116380-66-6

Formulation: A crystalline solid

Formal Name: (5β)-3α,7α,12α-trihydroxy-cholan-24-oic-2,2,4,4-d4 acid

Purity: ≥95%

Formula Markup: C24H36D4O5

Formula Weight: 412,6

Shelf life (days): 730

CAS Number: 116380-66-6

Notes: Cholic acid-d4 is intended for use as an internal standard for the quantification of cholic acid (Item No. 20250) by GC- or LC-MS. Cholic acid is a primary bile acid.{52692} It is formed from cholesterol via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. Cholic acid is conjugated to glycine or taurine by bile acid-CoA:amino acid N-acyltransferase (BAAT) to produce glycocholic acid (GCA; Item No. 20276) and taurocholic acid (TCA; Item No. 16215), respectively, in the liver, and is transformed into the secondary bile acid deoxycholic acid (DCA; Item No. 20756) by intestinal microbiota.{52692,61155,61156} It induces C. difficile colony formation in an agar dilution assay when used at a concentration of 0.1% w/v.{61157} Dietary administration of cholic acid (0.4% w/w) increases serum cholesterol levels, biliary phospholipid secretion, and fecal DCA levels in rats.{61158}

• Artikelnummer: CAY20849-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20849-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung