Ciclesonide, CAS 126544-47-6

Formulation: A crystalline solid

Formal Name: 16α,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11β-hydroxy-21-(2-methyl-1-oxopropoxy)-pregna-1,4-diene-3,20-dione

Purity: ≥98%

Formula Markup: C32H44O7

Formula Weight: 540,7

Shelf life (days): 1460

CAS Number: 126544-47-6

Notes: Ciclesonide (CIC) is a prodrug form of the glucocorticoid receptor agonist desisobutyryl-CIC (des-CIC).{29504} CIC binds to the glucocorticoid receptor with a Ki value of 37 nM.{29502} It is selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors. CIC inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation. Formulations containing CIC have been used in the maintenance treatment of asthma and in the treatment of allergic rhinitis.

• Artikelnummer: CAY18227-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 18227-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK