CMPF-d5

Formulation: A crystalline solid

Formal Name: 2-(2-carboxyethyl)-4-methyl-5-(propyl-2,2',3,3,3-d5)furan-3-carboxylic acid

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C12H11D5O5

Formula Weight: 245,3

Shelf life (days): 730

Notes: CMPF-d5 contains five deuterium atoms at the 2, 2', 3, 3, and 3 positions. It is intended for use as an internal standard for the quantification of CMPF (Item No. 10007133) by GC- or LC-mass spectrometry. Furan fatty acids are unique, naturally occurring lipids that are found in significant amounts in dietary phospholipids, such as in salmon roe.{13184} CMPF is an endogenous metabolite of furan fatty acids in humans. CMPF is highly albumin-bound and accumulates in the serum of uremic patients to concentrations in excess of 0.2 mM. Its primary effect is to inhibit cellular transport and subsequent deiodination of thyroxine (T4).{13104,13105} CMPF is tightly bound to albumin but only moderately inhibits T4 binding in a direct manner (10-14% at 0.3 mM). However, CMPF effectively displaces competitive T4 binding molecules from albumin, such as acidic drugs and free fatty acids.{13105} Therefore, CMPF may indirectly influence T4 binding to albumin by increasing the serum concentration of competitive binding molecules, particularly free fatty acids such as oleic acid.{13105}

• Artikelnummer: CAY9001871-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9001871-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung