Formulation: A solid
Formal Name: (11β)-11,21-dihydroxy-pregn-4-ene-3,20-dione-2,2,4,6,6,17,21,21-d8
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C21H22D8O4
Formula Weight: 354,5
Shelf life (days): 1460
CAS Number: 1271728-07-4
Notes: Corticosterone-d8 is intended for use as an internal standard for the quantification of corticosterone (Item No. 16063) by GC- or LC-MS. Corticosterone is a steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors.{26042} It is produced in response to adrenocorticotropic hormone (ACTH) and is the precursor to aldosterone synthesis.{19056} Since the production of glucocorticoids is increased by stress, it is often used as a biomarker of stress.{11468} Plasma corticosterone levels have a circadian variation and corticosterone may be important in the regulation of the sleep-wake cycle.{11469,11480}