Cytochalasin A, CAS 14110-64-6

Formulation: A crystalline solid

Formal Name: (3E,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-13-hydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,5,18-trione

Purity: ≥98%

Formula Markup: C29H35NO5

Formula Weight: 477,6

Shelf life (days): 1460

CAS Number: 14110-64-6

Notes: The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin A is an oxidized analog of cytochalasin B that uniquely inhibits HIV-1 protease (IC50 = 3 μM).{21311} Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (Ki = 4.0 and 0.6 μM, respectively).{21309,21308} Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 of Dictyostelium, activating STATc.{21304}

• Artikelnummer: CAY11327-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11327-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK