(-)-Deguelin, CAS 522-17-8

Formulation: A crystalline solid

Formal Name: 13,13aS-dihydro-9,10-dimethoxy-3,3-dimethyl-3H-[1]benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7aS)-one

Purity: ≥98%

Formula Markup: C23H22O6

Formula Weight: 394,4

Shelf life (days): 730

CAS Number: 522-17-8

Notes: (−)-Deguelin is a rotenoid that has been found in T. vogelii and has diverse biological activities.{51433,16334,16332,16314} It inhibits mitochondrial complex I, also known as NADH dehydrogenase, activity in bovine heart electron transport particles and phorbol 12-myristate 13-acetate-induced ornithine decarboxylase (ODC) activity in MCF-7 breast cancer cells (IC50s = 6.9 and 11 nM, respectively).{16334} (−)-Deguelin (100 nM) induces apoptosis in MCF-7 and SK-BR-3 breast cancer cells.{16332} It induces mortality in adult bruchid beetles (C. maculatus) when used at concentrations ranging from 10 to 500 ppm.{51433} (−)-Deguelin (6 mg/kg) induces nigrostriatal dopaminergic degeneration in rats.{16314}

• Artikelnummer: CAY10010706-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10010706-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK