Deoxycholic Acid-d4, CAS 112076-61-6

Formulation: A crystalline solid

Formal Name: (3α,5β,12α)-3,12-dihydroxy-cholan-24-oic-2,2,4,4-d4 acid

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C24H36D4O4

Formula Weight: 396,6

Shelf life (days): 1460

CAS Number: 112076-61-6

Notes: Deoxycholic acid-d4 (DCA-d4) is intended for use as an internal standard for the quantification of DCA (Item Nos. 20756 / 18231) by GC- or LC-MS. DCA is a secondary bile acid that is formed via microbial transformation of cholic acid (Item No. 20250) in the colon.{54006} It can be conjugated to glycine or taurine (Item No. 27031) to produce glycodeoxycholic acid (GDCA; Item No. 20274) or taurodeoxycholic acid (TDCA; Item No. 15935), respectively, in hepatocytes.{54006,33902,52692} DCA (0.2% v/v) inhibits spore germination induced by taurocholic acid (TCA; Item No. 16215) in seven C. difficile strains, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells when used at a concentration of 0.02% v/v.{54006} It inhibits ionizing radiation-induced p53-dependent transcription in a reporter assay using HCT116 cells when used at a concentration of 200 µM.{52693} Fecal and intestinal tissue levels of DCA are increased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.{54007} Increased serum DCA levels have been found in patients with colorectal cancer.{52694}

• Artikelnummer: CAY20851-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20851-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung