Docosahexaenoic Acid 1,2,3,4-13C

Formulation: A solution in ethanol

Formal Name: 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic-1,2,3,4-13C4 acid

Purity: ≥95%

Formula Markup: C18[13C]4H32O2

Formula Weight: 332,5

Shelf life (days): 365

Notes: Docosahexaenoic acid 1,2,3,4-13C (DHA 1,2,3,4-13C) is intended for use as an internal standard for the quantification of DHA (Item Nos. 90310 / 17950) by GC- or LC-MS. DHA is a long-chain ω-3 polyunsaturated fatty acid (PUFA) found in fish and algal oils.{65047} It comprises approximately 40% of total brain PUFAs and is abundant in grey matter and retinal membranes.{65048} DHA typically represents 0.52-7.5% of human total plasma fatty acids. It is produced from α-linolenic acid (ALA; Item Nos. 90210 / 21910) via a series of desaturase- and elongase-catalyzed reactions, resulting in a docosapentaenoic acid (DPA; Item Nos. 90165 / 21907) intermediate, which is elongated, desaturated, and β-oxidized to produce DHA.{65049} DHA can be liberated from cellular membranes by phospholipase A2 (PLA2) and converted to numerous oxylipins, including specialized pro-resolving mediators (SPMs), which are produced by lipoxygenases and include D-series protectins and resolvins, as well as maresins, that regulate host defense and the resolution of inflammation.{65050} DHA has roles in several physiological and pathological processes, including neural development, cardiovascular diseases, obesity, and inflammation.{65049,65051}

• Artikelnummer: CAY31104-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31104-50
• Green Labware: Nein
• Verpackungseinheit: 50 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung