Notes: Docosanol is an aliphatic alcohol that has broad-spectrum antiviral activity against viruses with a lipid envelope (ID50s = 3-12 nM for inhibition of replication).{41277} It inhibits herpes simplex virus type 1 (HSV-1) replication and protein synthesis in Vero cells.{41276} It also inhibits HSV-2 plaque formation and virus production in wild-type Vero cells and cells resistant to acyclovir (Item No. 14160). Docosanol acts by prohibiting the HSV envelope from fusing with the plasma membrane.{41277} Formulations containing docosanol have been used in the topical treatment of HSV-1.