EOS (d18:1/32:1/18:2), CAS 1318771-31-1

Formulation: A solution in dichloromethane

Formal Name: 9Z,12Z-octadecadienoic acid, (10Z)-32-[[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]amino]-32-oxo-10-dotriaconten-1-yl ester

Purity: ≥95%

Formula Markup: C68H127NO5

Formula Weight: 1038,8

Shelf life (days): 365

CAS Number: 1318771-31-1

Notes: EOS is a ceramide found in the outer layer of the epidermis in mammals.{34500} It is comprised of an ω-hydroxy very long-chain ceramide (C28-36) esterified to the essential fatty acid linoleic acid (Item No. 90150). The consecutive regio- and stereospecific oxygenation of the linoleate portion of EOS by 12(R)-lipoxygenase (12(R)-LO) and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss. Following oxygenation, the oxidized linoleate is hydrolyzed, leaving the ω-hydroxy end of the very long-chain fatty acid to covalently bind the protein layer, forming the corneocyte lipid envelope and sealing the gap between the extracellular lipid lamellae and the cornified cell envelope of the corneocyte.

• Artikelnummer: CAY22442-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22442-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Methode: Reinstoffe