Epothilone B, CAS 152044-54-7

Formulation: A crystalline solid

Formal Name: 7S,11S-dihydroxy-8,8,10R,12S,16R-pentamethyl-3S-[(1E)-1S-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

Purity: ≥95%

Formula Markup: C27H41NO6S

Formula Weight: 507,7

Shelf life (days): 1460

CAS Number: 152044-54-7

Notes: Epothilone B (Epo B) is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.{19711,19713} It induces mitotic arrest at the G2-M transition in Hs578T and HeLa cells (IC50 = 3 and 32 nM, respectively) as well as in multidrug resistant KB3-1 and KBV-1 cells (IC50 = 16 and 92 nM, respectively).{19711} Epo B causes cell cycle arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer.{19714}

• Artikelnummer: CAY10924-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10924-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK