Fulvestrant, CAS 129453-61-8

Formulation: A crystalline solid

Formal Name: 7α-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-estra-1,3,5(10)-triene-3,17β-diol

Purity: ≥98%

Formula Markup: C32H47F5O3S

Formula Weight: 606,8

Shelf life (days): 1460

CAS Number: 129453-61-8

Notes: Fulvestrant is a selective estrogen receptor degrader (SERD) that downregulates and degrades estrogen receptor α (ERα).{16606,43228} It binds to rat uterine ER with an IC50 value of 44.8 nM and prevents uterine weight increases induced by estradiol in immature rats (ED50> = 0.06 mg/kg per day) but has no effect on uterine weight alone.{43229} It also decreases uterine weight in adult rats without affecting the production of luteinizing and follicle-stimulating hormones and prolactin. Fulvestrant inhibits the growth of ER-positive MCF-7 human breast cancer cells but not ER-negative BT-20 cells when used at a concentration of 1 µg/ml. It also prevents tumor growth in MCF-7 and Br10 breast cancer mouse xenograft models when used at a single dose of 5 mg per animal. Fulvestrant is neuroprotective in vitro against neurotoxicity induced by glutamate- and amyloid-β (1-42) (Aβ42) in primary rat hippocampal cells.{16605} Formulations containing fulvestrant have been used in the treatment of estrogen-sensitive breast cancer.

• Artikelnummer: CAY10011269-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10011269-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK