Galactosylsphingosine (d18:1) (synthetic), CAS 2238-90-6

Formulation: A solid

Formal Name: (2S,3R,4E)-2-amino-3-hydroxy-4-octadecen-1-yl β-D-galactopyranoside

Purity: ≥98%

Formula Markup: C24H47NO7

Formula Weight: 461,6

Shelf life (days): 1460

CAS Number: 2238-90-6

Notes: Galactosylsphingosine is a bioactive sphingolipid.{32334,32333,15202} It potentiates LPS-induced production of inflammatory cytokines, decreases the mitochondrial membrane potential, and induces cell death in mouse astrocytes, effects that can be reversed by the sphingosine-1-phosphate receptor agonist FTY720 phosphate (Item No. 10008639).{32334} Galactosylsphingosine (0.1 and 1 µM) induces demyelination of mouse cerebellar slices. It inhibits PDGF-induced translocation of PKC to the cell surface and induces apoptosis in MO3.13 oligodendrocytes.{32033} Galactosylsphingosine (10 and 15 µM) inhibits gene transcription mediated by peroxisome proliferator-activated receptor α (PPARα) in reporter assays using C6 glial cells.{54403} Levels of galactosylsphingosine are increased in postmortem brain from patients with Krabbe disease, a lysosomal storage disorder characterized by a β-galactosylceramidase deficiency.{32334,32333,15202,54403} [Matreya, LLC. Catalog No. 2087]

• Artikelnummer: CAY31594-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31594-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK