Ginkgetin, CAS 481-46-9

Formulation: A crystalline solid

Formal Name: 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Purity: ≥98%

Formula Markup: C32H22O10

Formula Weight: 566,5

Shelf life (days): 1460

CAS Number: 481-46-9

Notes: Ginkgetin is a biflavonoid that has been isolated from G. biloba and has diverse biological activities, including pro-apoptotic, antiproliferative, anti-inflammatory, anti-atherosclerosis, and neuroprotective properties.{36713,36714,36715,36716} It inhibits the proliferation of OVCAR-3 ovarian and HeLa cervical cancer cells (EC50s = 3 and 5.2 μg/ml, respectively) and induces apoptosis and caspase-3 cleavage in OVCAR-3 cells when used at a concentration of 3 μg/ml.{36713} Topical ginkgetin (20 μg/ear) reduces ear edema and prostaglandin E2 (PGE2; Item No. 14010) levels in a mouse model of chronic skin inflammation induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{36714} It decreases the thickness of the intima-media and lipid plaque deposition in the thoracic aorta in a rat model of high-fat diet-induced atherosclerosis when administered at a dose of 100 mg/kg.{36715} Ginkgetin (0.8 mg/kg per day) improves sensorimotor coordination and increases the time spent on a rotating bar in a mouse model of Parkinson's disease induced by MPTP.{36716}

• Artikelnummer: CAY25103-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25103-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK