Globotriaosylceramide (hydroxy) (porcine RBC)

Formulation: A solid

Purity: ≥98%

Formula Markup: C60H113NO19 (for hydroxytetracosanoyl)

Formula Weight: 1152,6

Shelf life (days): 1460

Notes: Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides (Item No. 16983).{38975} They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo.{38976} Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A.{38977} Globotriaosylceramides act as natural resistance factors to HIV infection, interacting with HIV gp120 to prevent its interaction with chemokine co-receptors and subsequent fusion of HIV to host cell membranes.{38975} This product contains hydroxy fatty acid-containing globotriaosylceramide molecular species with primarily 2-hydroxy C24:0 and 2-hydroxy C24:1 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1514]

• Artikelnummer: CAY24872
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24872-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK