Glycine-β-muricholic Acid, CAS 66225-78-3

Formulation: A crystalline solid

Formal Name: N-[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]-glycine

Purity: ≥95%

Formula Markup: C26H43NO6

Formula Weight: 465,6

Shelf life (days): 1460

CAS Number: 66225-78-3

Notes: Glycine-β-muricholic acid (GβMCA) is an intestine-selective antagonist of the farnesoid X receptor (FXR) and the glycine-conjugated form of the murine-specific primary bile acid β-muricholic acid (Item No. 20287).{36870,45190} It inhibits expression of the FXR target genes Shp and Fgf15 induced by the FXR ligands chenodeoxycholic acid (Item No. 10011286) and GW 4064 (Item No. 10006611) in Caco-2 cells when used at a concentration of 100 μM. GβMCA is resistant to hydrolysis by fecal bile salt hydrolase (BSH) isolated from gut microbiota, indicating gut stability. Dietary administration of GβMCA (10 mg/kg) decreases Shp and Fgf15 mRNA expression in ileum, but not liver, and reduces ceramide levels and expression of the ceramide synthesis-related genes Sptlc2, Sptlc3, Cers2, Cers4, Degs1, Degs2, Smpd3, and Smpd4 in ileum of mice with high-fat diet-induced obesity and db/db mice. It also prevents weight gain, reduces blood glucose levels, and increases insulin sensitivity as well as prevents development of cholestasis and necrotic lesions in liver of mice with high-fat diet-induced obesity.

• Artikelnummer: CAY9003230-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9003230-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK