Glycodeoxycholic Acid-d4 MaxSpec® Standard, CAS 1069132-37-1

Formulation: A solution in methanol at 100 µg/ml

Formal Name: N-[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]-glycine

Purity: ≥95%

Formula Markup: C26H39D4NO5

Formula Weight: 453,7

Shelf life (days): 1825

CAS Number: 1069132-37-1

Notes: Glycodeoxycholic acid-d4 (GDCA-d4) is intended for use as an internal standard for the quantification of glycodeoxycholic acid (Item No. 20274) by GC- or LC-MS. GDCA is a glycine-conjugated form of the secondary bile acid deoxycholic acid (Item Nos. 18231 / 20756).{48223} It induces a reversible, concentration-dependent reduction in myogenic tone in rats and decreases expression of the gene encoding the cytochrome P450 (CYP) isoform 7A1 (CYP7A1) in rabbits.{33912,33913} Serum levels of GDCA are elevated in non-surviving patients with acetaminophen-induced acute liver failure (AALF) compared with survivors.{33914} GDCA levels are also increased in the plasma of patients with asthma.{33911} Glycodeoxycholic acid-d4 MaxSpec® standard is a quantitative grade standard of glycodeoxycholic acid-d4 (Item No. 31310) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This glycodeoxycholic acid-d4 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

• Artikelnummer: CAY31553
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31553-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung