Hydrocortisone-d4, CAS 73565-87-4

Formulation: A solid

Formal Name: (11β)-11,17,21-trihydroxy-pregn-4-ene-3,20-dione-9,11,12,12-d4

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C21H26D4O5

Formula Weight: 366,5

Shelf life (days): 1460

CAS Number: 73565-87-4

Notes: Hydrocortisone-d4 is intended for use as an internal standard for the quantification of hydrocortisone/cortisol (Item No. 20739) by GC- or LC-MS. Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH).{11860,47112} It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR), with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response.{47112} Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson's disease.{11854,11861,47113}

• Artikelnummer: CAY26500-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26500-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung