Ionizable Lipid 4, CAS 1799316-81-6

Formulation: A solution in methyl acetate

Formal Name: 9,12-octadecadienoic acid, (9Z,12Z)-1,1′-[2-[[[[3-(diethylamino)propoxy]carbonyl]oxy]methyl]-1,3-propanediyl] ester

Purity: ≥95%

Formula Markup: C48H85NO7

Formula Weight: 788,2

Shelf life (days): 1460

CAS Number: 1799316-81-6

Notes: Ionizable lipid 4 is an ionizable cationic lipid (pKa = 6.1) and a hydrogen peroxide-induced rearrangement product of the cationic lipid CA-lipid 5.{68757} Charge-altering lipid nanoparticles (CALNPs) containing CA-lipid 5 and encapsulating siRNA against EGFP undergo hydrogen peroxide-induced removal of the phenylboronic acid groups from CA-lipid 5 in MCF-7 cells in vitro, generating ionizable lipid 4-containing LNPs with reduced positive charges at physiological pH, facilitating intracellular siRNA release and gene silencing. LNPs containing ionizable lipid 4 and encapsulating siRNA against PLK1 reduce tumor volume in an MCF-7 mouse xenograft model less effectively than CALNPs containing CA-lipid 5.

• Artikelnummer: CAY40496-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 40496-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK