Isosinensetin, CAS 17290-70-9

Formulation: A solid

Formal Name: 2-(3,4-dimethoxyphenyl)-5,7,8-trimethoxy-4H-1-benzopyran-4-one

Purity: ≥98%

Formula Markup: C20H20O7

Formula Weight: 372,4

Shelf life (days): 1460

CAS Number: 17290-70-9

Notes: Isosinensetin is a polymethoxylated flavone that has been found in C. reticulata and has anticancer and anti-inflammatory activities.{47468,64547,64548} It inhibits P-glycoprotein (P-gp; IC50 = 4.2 µM) and increases the cytotoxicity of paraquat in MDR1-MDCKII cells and paclitaxel (Item No. 10461) in MX-1 breast and paclitaxel-resistant MX-1/T cancer cells.{47468} Isosinensetin inhibits the proliferation of A549 lung, HL-60 leukemia, MCF-7 breast, and HO-8910 ovarian cancer cells (IC50s = 23.6, 23.8, 15.1, and 12.5 µM, respectively).{64547} It prevents decreases in cell viability and inhibits increases in IL-1β, TNF-α, and IL-6 levels and the production of reactive oxygen species (ROS) induced by fine particulate matter less than or equal to 2.5 µm (PM2.5) in 16HBE bronchial epithelial cells when used at a concentration of 80 µg/ml.{64548}

• Artikelnummer: CAY36009-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36009-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe