Jacaric Acid, CAS 28872-28-8

Formulation: A solution in ethanol

Formal Name: 8Z,10E,12Z-octadecatrienoic acid

Purity: ≥95%

Formula Markup: C18H30O2

Formula Weight: 278,4

Shelf life (days): 730

CAS Number: 28872-28-8

Notes: Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants.{30028} Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid (Item No. 90220). Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 µM).{30024,25889,30026} It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress.{25889,30026} Jacaric acid is metabolized in vivo to conjugated linoleic acid (Item No. 90140), which is also cytotoxic to cancer cells.{6849} Jacaric acid inhibits cyclooxygenase-1 in vitro (Ki = 1.7 µM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.{37087,30029}

• Artikelnummer: CAY16036-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16036-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK