L-threo-Sphingosine (d18:1), CAS 25695-95-8

Formulation: A crystalline solid

Formal Name: 2S-amino-4E-octadecene-1,3S-diol

Purity: >98%

Formula Markup: C18H37NO2

Formula Weight: 299,5

Shelf life (days): 730

CAS Number: 25695-95-8

Notes: Sphingosines are long-chain base precursors of cellular sphingolipids and are used directly in the synthesis of ceramide. Sphingosine can exist in four stereoisomers, however only D-erythro-sphingosine occurs naturally. L-threo-Sphingosine C-18, an analog of D-erythro-sphingosine, inhibits protein kinase C in mixed micelle assays with 50% inhibition at 2.2 mol % making it a slightly more potent inhibitor compared to D-erythro-sphingosine (50% inhibition at 2.8 mol %) or other analogs of shorter alkyl chain length.{15200} Addition of L-threo-Sphingosine C-18 to primary cultured cerebellar cells does not decrease serine palmitoyltransferase (SPT) activity, the rate-limiting enzyme in ceramide biosynthesis, whereas under similar conditions D-erythro-sphingosine inhibits SPT activity.{15203}

• Artikelnummer: CAY10010541-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10010541-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK