Leukotriene A4 methyl ester, CAS 73466-12-3

Formulation: A solution in hexane containing 1% triethylamine

Formal Name: 5S-trans-5,6-oxido-7E,9E,11Z,14Z-eicosatetraenoic acid, methyl ester

Purity: ≥97%

Formula Markup: C21H32O3

Formula Weight: 332,5

Shelf life (days): 365

CAS Number: 73466-12-3

Notes: Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities.{595,482} LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively.{482} LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells.{781} Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis.{482} LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.

• Artikelnummer: CAY20010-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20010-25
• Green Labware: Nein
• Verpackungseinheit: 25 µg
• Mengeneinheit: STK