Leukotriene B4-d5

Formulation: A solution in ethanol

Formal Name: (5S,6Z,8E,10E,12R,14Z)-5S,12R-dihydroxyicosa-6Z,8E,10E,14Z-tetraenoic-19,19,20,20,20-d5 acid

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C20H27D5O4

Formula Weight: 341,5

Shelf life (days): 365

Notes: Leukotriene B4-d5 (LTB4-d5) is intended for use as an internal standard for the quantification of LTB4 (Item No. 20110) by GC- or LC-MS. LTB4 is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase (5-LO) pathway.{521,719,948} It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10−10 M), LTB4 induces chemotaxis and chemokinesis in human polymorphonuclear leukocytes.{329} At higher concentrations, (1.0 x 10−7 M), LTB4 leads to neutrophil aggregation and degranulation as well as superoxide anion production.{329,82}

• Artikelnummer: CAY36097-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36097-25
• Green Labware: Nein
• Verpackungseinheit: 25 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung