Lyso-Monosialoganglioside GM1 (ammonium salt)

Formulation: A solid

Formal Name: (2S,3R,4E)-2-amino-3-hydroxy-4-octadecenyl O-(N-acetyl-α-neuraminosyl)-(2→3)-O-[O-β-D-galactopyranosyl-(1→3)-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl-(1→4)]-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside, monoammonium salt

Purity: ≥98%

Formula Markup: C55H96N3O30 • NH4

Formula Weight: 1297,4

Shelf life (days): 1460

Notes: Lyso-monosialoganglioside GM1 (Lyso-GM1) is a form of ganglioside GM1 (Item No. 19579) that is lacking the fatty acyl group. Lyso-GM1 (2.5 µM) inhibits laminin-1-induced clustering of ganglioside GM1 in dorsal root ganglion (DRG) cells and also disrupts β1 integrin clustering and neurite outgrowth.{38938} It does not protect against glutamate-induced neurotoxicity in primary neuronal cultures.{38939} Elevated levels of lyso-GM1 have been found in the brain and spinal cord of patients with infantile- and late-infantile-type GM1-gangliosidosis, a neurodegenerative disorder characterized by deficiency of the enzyme β-galactosidase and accumulation of gangliosides.{38940} As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1518]

• Artikelnummer: CAY24837
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24837-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK