Maresin 1-d5

Formulation: A solution in ethanol

Formal Name: 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic-21,21,22,22,22-d5 acid

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C22H27D5O4

Formula Weight: 365,5

Shelf life (days): 365

Notes: Maresin 1-d5 is intended for use as an internal standard for the quantification of maresin 1 (Item No. 10878) by GC- or LC-MS. Maresin 1 is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.{27956} It is produced from docosahexaenoic acid (DHA; Item Nos. 90310 / 17950) in human peripheral blood mononuclear cells (PBMCs). Maresin 1 (100 nM) reduces TNF-α-induced increases in reactive oxygen species (ROS) in primary human vascular smooth muscle and endothelial cells.{28026} It decreases disease severity, neutrophil infiltration, and intestinal crypt damage in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250) when administered at doses of 0.3 and 1 µg/animal.{28042} Maresin 1 (0.1, 1, and 10 ng/animal) inhibits increases in inflammatory exudate polymorphonuclear (PMN) neutrophil infiltration in a mouse model of peritonitis induced by zymosan A (Item No. 21175).{27956} It has been found in the synovial fluid of rheumatoid arthritis patients.{30501}

• Artikelnummer: CAY21823-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21823-10
• Green Labware: Nein
• Verpackungseinheit: 10 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung