MCTR2, CAS 1784701-62-7

Formulation: A solution in ethanol

Formal Name: S-[(1R,2E,4E,6Z,9Z)-12-carboxy-1-[(1S,3Z,6Z)-1-hydroxy-3,6-nonadien-1-yl]-2,4,6,9-dodecatetraen-1-yl]-L-cysteinyl-glycine

Purity: ≥97%

Formula Markup: C27H40N2O6S

Formula Weight: 520,7

Shelf life (days): 365

CAS Number: 1784701-62-7

Notes: Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; Item No. 90310) in macrophages at the site of inflammation.{29715,33727} DHA is oxidized to maresin 1 (MaR1; Item No. 10878), which is converted to MCTR1 (Item No. 17007) by glutathione S-transferase Mu 4 or leukotriene C4 synthase then to MCTR2 by γ-glutamyl transferase.{33713} MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM).{33727} Pretreatment with MCTR2 prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages.{33727} When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR2 selectively reduced the amount of the eicosanoids PGD2 (Item No. 12010) and PGF2α (Item No. 16010) in the exudate.{33727}

• Artikelnummer: CAY17008-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 17008-10
• Green Labware: Nein
• Verpackungseinheit: 10 µg
• Mengeneinheit: STK