Formulation: A crystalline solid
Formal Name: 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosaheptaen-1-yl]-3-methyl-1,4-naphthalenedione
Purity: ≥98%
Formula Markup: C46H64O2
Formula Weight: 649
Shelf life (days): 1460
CAS Number: 2124-57-4
Notes: Menaquinone 7 (MK-7) is a vitamin K2 analog that has been found in a variety of fermented foods.{41834} It increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells. MK-7 (1 µM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats.{41835} In vivo, MK-7 (100 µg/g diet) inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification.{41836} It also increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss.{41837}