Methylprednisolone, CAS 83-43-2

Formulation: A crystalline solid

Formal Name: 11β,17,21-trihydroxy-6α-methyl-pregna-1,4-diene-3,20-dione

Purity: ≥98%

Formula Markup: C22H30O5

Formula Weight: 374,5

Shelf life (days): 1460

CAS Number: 83-43-2

Notes: Methylprednisolone is a synthetic glucocorticoid, an agonist of glucocorticoid and mineralocorticoid receptors, and an active metabolite of the prodrug 6α-methylprednisolone 21-hemisuccinate (MPS; Item Nos. 11800 / 35742).{41565} It transactivates glucocorticoid and mineralocorticoid receptors in a reporter assay using CV-1 cells (EC50s = 2.92 and 2.31 nM for the human receptors, respectively). Methylprednisolone (40 mg/kg) reduces endotoxin-induced complement activation in rabbits.{4407} It induces T cell apoptosis and reduces the number of T cell spinal cord infiltrates in a rat model of experimental autoimmune encephalomyelitis (EAE) when administered at a dose of 50 mg/kg.{51446} It decreases the number of reactive spinal astrocytes, improves proprioceptive limb placing and coordination, and reduces spinal edema and the number of spinal necrotic cells in a rat model of spinal crush injury.{42987} Formulations containing methylprednisolone have been used in the treatment of immune and autoimmune disorders, such as rheumatoid arthritis, systemic lupus erythematosus, psoriasis, corneal ulcers, ulcerative colitis, and allergies, among others.

• Artikelnummer: CAY15013-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 15013-1
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK