Misoprostol (free acid), CAS 112137-89-0

Formulation: A solution in methyl acetate

Formal Name: 11α,16-dihydroxy-16-methyl-9-oxo-prost-13E-en-1-oic acid

Purity: ≥97%

Formula Markup: C21H36O5

Formula Weight: 368,5

Shelf life (days): 365

CAS Number: 112137-89-0

Notes: Misoprostol is a prostaglandin E1 (Item No. 13010) analog with agonist activity mediated by EP2, EP3, and EP4 receptors.{2313,1754,1752,1611} It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 µg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 µM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner.{1754,1752,1611} Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; Item No. 10006317) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.{2313}

• Artikelnummer: CAY13821-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 13821-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK