Misoprostol (free acid)-d5, CAS 1337917-44-8

Formulation: A solution in methyl acetate

Formal Name: 9-oxo-11α,16-dihydroxy-16-(methyl-d3)-prost-13E-en-1-oic-17,17-d2 acid

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C21H31D5O5

Formula Weight: 373,5

Shelf life (days): 365

CAS Number: 1337917-44-8

Notes: Misoprostol (free acid)-d5 contains five deuterium atoms at the 16 methyl, 17, and 17' positions. It is intended for use as an internal standard for the quantification of misoprostol (free acid) by GC- or LC-mass spectrometry (MS). Misoprostol is a PGE1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors.{2313,1754,1752,1611} It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 µg/kg),{1754} inhibit superoxide generation in human neutrophils (EC50 = 0.35 µM),{1752} and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM){1611} in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with RU-486 for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.{2313}

• Artikelnummer: CAY10010333-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10010333-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung