N-Arachidonoyl Taurine-d4

Formulation: A solution in ethanol

Formal Name: 2-((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenamido)ethane-1-sulfonic-1,1,2,2-d4 acid

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C22H33D4NO4S

Formula Weight: 415,6

Shelf life (days): 365

Notes: N-Arachidonoyl taurine-d4 is intended for use as an internal standard for the quantification of N-arachidonoyl taurine (Item No. 10005537) by GC- or LC-MS. N-Arachidonoyl taurine is an arachidonoyl amino acid.{16245} It is oxygenated by 12(S)- and 15(S)-lipoxygenase and is converted to 12-HETE-taurine (12-HETE-T) in murine resident peritoneal macrophages.{46067} N-Arachidonoyl taurine is an activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4 (EC50s = 28 and 21 µM, respectively).{16245} It increases calcium flux in HIT-T15 pancreatic β-cells and INS-1 rat islet cells when used at a concentration of 10 µM and increases insulin secretion from 832/13 INS-1 pancreatic β-cells.{46068} The levels of N-arachidonoyl taurine are changed in mouse brain following administration of Δ9-tetrahydrocannabinol (Δ9-THC).{46069}

• Artikelnummer: CAY26323-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26323-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung