N-glycolyl-Ganglioside GM3 Mixture (ammonium salt), CAS 69345-49-9

Formulation: A solid

Formal Name: 1-O-[O-[N-(hydroxyacetyl)-α-neuraminosyl]-(2→3)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]-ceramide

Purity: ≥98%

Formula Markup: C64H117N2O22 • NH4 (for tricosanoyl)

Formula Weight: 1284,7

Shelf life (days): 1460

CAS Number: 69345-49-9

Notes: N-glycolyl-Ganglioside GM3 (NeuGc-GM3) is a form of ganglioside GM3 that contains an N-glycolylated sialic acid (NeuGc). It is not biosynthesized in humans under baseline conditions due to a mutation in CMP-Neu5Ac hydroxylase (CMAH), which converts N-acetyl sialic acid to N-glycolyl sialic acid, but NeuGc can be taken up by human cells via the diet and incorporated into glycolipids, such as ganglioside GM3.{54575,60205} NeuGc-GM3 impairs differentiation and maturation of dendritic cells in vitro and reduces CD4 expression in non-activated T cells.{54575,60206} It increases the number of lung tumor nodules formed in a murine Lewis lung carcinoma model.{60207} It is found in a variety of human cancers, including breast and lung cancers, as well as pediatric cancers.{54575} Levels of NeuGc-GM3 are negatively correlated with the number of mature dendritic cells in patient-derived non-small cell lung cancer (NSCLC) tumor tissue.{60208} Anti-NeuGc-GM3 antibodies, able to destroy tumor cells in vitro, have been found in individuals without cancer but not in patients with NSCLC.{54575,60209} N-glycolyl-Ganglioside GM3 mixture contains ganglioside GM3 molecular species with primarily C22:0, C23:0, and C24:0 fatty acyl chain lengths. As this product is derived from a natural source, there may also be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1553]

• Artikelnummer: CAY33263
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33263-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK