N-Oleoyl Dopamine, CAS 105955-11-1

N-Oleoyl Dopamine, CAS 105955-11-1
Artikelnummer
CAY10115-50
Verpackungseinheit
50 mg
Hersteller
Cayman Chemical

Verfügbarkeit: wird geladen...
Preis wird geladen...
Formulation: A crystalline solid

Formal Name: N-[2-(3,4-dihydroxyphenyl)ethyl]-9Z-octadecenamide

Purity: ≥98%

Formula Markup: C26H43NO3

Formula Weight: 417,6

Shelf life (days): 365

CAS Number: 105955-11-1

Notes: N-Oleoyl dopamine (ODA) is a selective, endogenous vanilloid receptor 1 (VR1) agonist isolated from bovine brain.{11117} Structurally, it is the amide of oleic acid and dopamine and is therefore a “hybrid” analog which incorporates components of both the anandamide-like and dopamine neurotransmitter pathways. ODA binds to the human recombinant VR1 with a Ki of 36 nM making it equipotent to capsaicin and slightly more potent than N-arachidonoyl dopamine in this assay.{11117} It causes hyperalgesia and nocifensive behavior that is blocked by the VR1 antagonist iodo-resiniferatoxin. ODA is selective for VR1 based on observations that it has weak affinity for the rat CB1 receptor (Ki of 1.6 µM) and is a very weak inhibitor of FAAH. ODA is also a potent inhibitor of 5-lipoxygenase from rat basophilic leukemia-1 (RBL-1) cells, with a IC50 of 7.5 nM.{11036,11037}
Mehr Informationen
Artikelnummer CAY10115-50
Hersteller Cayman Chemical
Hersteller Artikelnummer 10115-50
Green Labware Nein
Verpackungseinheit 50 mg
Mengeneinheit STK
Produktinformation (PDF) Download
MSDS (PDF) Download