Naringenin, CAS 67604-48-2

Formulation: A crystalline solid

Formal Name: 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Purity: ≥98%

Formula Markup: C15H12O5

Formula Weight: 272,3

Shelf life (days): 1460

CAS Number: 67604-48-2

Notes: Naringenin is a citrus-derived flavonoid that inhibits CYP3A4 activity in human liver microsomes (IC50s = 139-188 μM).{18074,22311} At 100 mg/kg/day, naringenin selectively inhibits the transcription of Smad3 and directly down-regulates TGF-β1, significantly reducing lung metastasis in mice with bleomycin-induced pulmonary fibrosis.{22310} Naringenin demonstrates both lipid lowering and insulin-like properties in low-density lipoprotein (LDL) receptor-deficient mice fed a Western diet containing 1-3% naringenin by correcting VLDL overproduction, ameliorating hepatic steatosis, and attenuating dyslipidemia without affecting caloric intake or fat absorption.{22309}

• Artikelnummer: CAY14173-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 14173-5
• Green Labware: Nein
• Verpackungseinheit: 5 g
• Mengeneinheit: STK